Quick answer
✅ Yes — comfortably. A physician assistant in St. Louis earns roughly $109,809/yr (~$5,985/mo take-home) and a 1BR costs $1,100/mo — that's 18% of take-home on rent. The standard is 30% or less.
MO · 2026
Can a Physician Assistant Afford to Live in St. Louis?
Using local salary estimates and St. Louis's actual cost of living — rent, taxes, utilities, and groceries — here's the real monthly picture for a physician assistant in St. Louis, MO in 2026.
Monthly Budget Breakdown
Gross monthly salary
$109,809/yr local estimate
$9,151
Taxes (federal + state + FICA)
Up to 4.95% state income tax
-$3,166
Monthly take-home
After all taxes
$5,985
1BR rent
18% of take-home
-$1,100
Utilities
Electric, gas, internet avg
-$145
Groceries
Single-person estimate
-$335
Transport
Car or transit average
-$350
Left for everything else
Dining, clothing, fun, savings
$4,055
At a 40% savings rate on discretionary income, a physician assistant in St. Louis could save roughly $19,464/year after covering all essentials.
What Does 18% Rent Burden Mean?
The standard rule of thumb is to spend no more than 30% of gross income on rent. At 18% of take-home pay, a physician assistant in St. Louis is well within a healthy range — leaving solid room for savings and discretionary spending.
These numbers use a local salary estimate of $109,809/yr — adjusted from the national Physician Assistant median of $126,010/yr based on St. Louis's cost of living index. Actual salaries vary by employer, experience, and specialization.
Best Neighborhoods in St. Louis for a Physician Assistant
Based on walkability, rent levels, and quality of life — not just lowest price.
Clayton
Walkable WashU-adjacent suburb, excellent restaurants, corporate offices, most livable; 1BR $1,300–1,800
The Hill
Italian-American community, Toasted Ravioli birthplace, best Italian food in Midwest; 1BR $1,000–1,400
Lafayette Square
Victorian homes, park, established young professionals, South St. Louis feel; 1BR $1,000–1,400
Frequently Asked Questions
What is the average salary for a Physician Assistant in St. Louis?
A Physician Assistant in St. Louis earns approximately $109,809 per year, based on the national BLS median of $126,010/yr adjusted for St. Louis's cost of living. Actual pay varies by employer, experience, and specialization.
Is St. Louis affordable for a physician assistant in 2026?
Yes. Rent takes around 18% of take-home pay — below the 30% guideline. A physician assistant can live comfortably in St. Louis with room to save.
How much take-home pay does a Physician Assistant get in St. Louis?
After federal taxes, Up to 4.95% state income tax, and FICA, a Physician Assistant earning $109,809/yr takes home roughly $5,985/month in St. Louis.
What is the rent-to-income ratio for a Physician Assistant in St. Louis?
A 1-bedroom apartment in St. Louis costs a median of $1,100/month. On a Physician Assistant salary, that's 18% of monthly take-home pay. Financial experts recommend keeping this below 30%.